Circulating microrna-92a and microrna-21 as novel minimally invasive biomarkers for primary breast cancer terpenning m, giuliano ae, hoon ds (2011) direct serum assay for microrna-21 concentrations in early and advanced breast cancer krogh a, lund ah (2008) programmed cell death 4 (pdcd4) is an important functional target of the. Our results showed that the serum concentrations of mir 21 and mir155 were significantly elevated, while mir365 was significantly downregulated in patients with breast cancer compared with. Mircancer : microrna cancer association database mircancer provides comprehensive collection of microrna (mirna) expression profiles in various human cancers which are automatically extracted from published literatures in pubmedit utilizes text mining techniques for information collection.
Background and aims ovexpression of microrna-21 (mir-21) is found in various human cancers our aim is to investigate the association of mir-21 expression with the sensitivity of breast cancer cells to doxorubicin (adr. More importantly, recent studies investigating its association with cancer outcomes have disclosed the prognostic value of mir-21, with its high expression predicting worse survival status in malignancies including breast cancer, lung cancer, pancreatic cancer, colorectal cancer, and so on . Previous studies have illuminated that mir-21-5p was high levels and be able to promote tumor invasion, intravasation and metastasis in various types of cancers (including colorectal cancer, gc.
When cancer is resistant to a treatment it means the cancer cells aren't weakened or destroyed by the treatment any more a study suggests that too much microrna-21 (mirna-21) in her2-positive breast cancer cells is linked to herceptin resistance these results were reported at the 2010 american. Microparticle conferred microrna profiles - implications in the transfer and dominance of cancer traits in breast cancer, terpenning m, giuliano ae, hoon dsb: direct serum assay for microrna-21 concentrations in early and advanced breast cancer clin chem 2011, 57 (1):. Among the large number of micrornas , the excessive expression of microrna-21 has been found in the serum of cancer patients, including medulloblastoma , glioblastoma , colon cancer , hepatocellular cancer , and breast cancer , when compared to the corresponding normal tissues.
Women with metastatic breast cancer, especially csii, presented up-regulated levels of mir-183, mir-494 and mir-21, which were associated with a poor prognosis these mirnas therefore represent new risk biomarkers of breast cancer metastasis and may be useful for future targeted therapies. Cancer cells including breast cancer, colorectal cancer (asangani et al, 2008) and glioma (gabriely et al, 2008), concentrations of all rna samples were measured using nanodrop spectrophotometer regulation of serum mir-21 in ovarian cancer serum samples microrna-21 was significantly up – regulated while. Mirna-21, mirna-155, mirna-196a and mirna-210, which are known to be associated with pancreatic cancer, were also found to be elevated in the plasma of pancreatic carcinoma patients [28, 61] these mirnas have been largely studied for their functional consequences: mirna-21 is known to be upregulated in several tumor entities and targets known. Direct serum assay for microrna-21 concentrations in early and advanced breast cancer abstract background – small noncoding rna molecules known as micrornas (mirs) are involved in the regulation of gene expression. The aim of this study is to determine whether microrna-21 (mir-21), a specific microrna implicated in multiple aspects of carcinogenesis, promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 (timp-3) gene.
Identification of serum microrna-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma asaga et al 31 found that serum mir-21 concentrations had diagnostic and prognostic potential in breast cancer direct serum assay for microrna-21 concentrations in early and advanced breast. Colorectal cancer (crc) is the second leading cause of cancer related deaths in the united states early detection increases survival very significantly indeed, five year survival for people diagnosed at stage i-ii is 90%, while for those diagnosed at stage iv it is only 13% the gold standard for. On the other hand, the two most promising qpcr candidate mirnas, circulating mir-21 and mir-155, which were consistently reported as 25 to 35-fold higher in breast cancer by independent groups, were directly contradicted by genome-wide results, showing that both were down in breast cancer.
Asaga s, kuo c, nguyen t, terpenning m, giuliano ae, hoon ds: direct serum assay for microrna-21 concentrations in early and advanced breast cancer clin chem 2011, 57: 84-91 view article pubmed google scholar. Keywords: microrna, microarray, real time pcr, breast cancer, prognosis, mir-21 in this study, we investigated the global mirna expression profile in primary bc to evaluate their involvement in malignant progression of this tumor to this end, we examined the up-regulation of mir-21 in 113 bc cases. Laboratory of human carcinogenesis, center for cancer research, national cancer institute, national institutes of health, 37 convent drive, building 37, room 3068, bethesda, md 20892, usa published 2012 this article is a us government work and, as such, is in the public domain in the united.
Serum microrna-21 as marker for necroinflammation in hepatitis c patients with and without hepatocellular carcinoma direct serum assay for microrna-21 concentrations in early and advanced breast cancer is an important functional target of the microrna mir-21 in breast cancer cells. Direct serum assay for microrna-21 concentrations in early and advanced breast cancer. Biomarkers 18: 687 – 98 [taylor & francis online] it has been reported that mir-21 is overexpressed in breast cancer (asaga et al, 2011), lung cancer (liu et al, direct serum assay for microrna-21 concentrations in early and advanced breast cancer. Results: the assay was sensitive for detection of mir-21 in 0625 μl of serum from breast cancer patients for differentiation of samples from patients with locoregional breast cancer from those from healthy donors, the odds ratio was 1796 and the area under the curve was 0721.
Microrna 21 also known as hsa-mir-21 or mirna21 is a mammalian microrna that is encoded by the mir21 gene mirn21 was one of the first mammalian micrornas identified the mature mir-21 sequence is strongly conserved throughout evolution. Growth of breast cancer cells in vitro, but the mechanisms, which may involve microrna (mirna), are still unclear the expression of the oncomir, mir-21, is reduced by dha treatment, but the. Aberrant expression of microrna-21 (mir-21) has previously been reported in breast cancer tissue the aim of this study was to investigate expression levels of serum mir-21 in breast cancer patients and evaluate its prognostic value in chinese females. Microrna-21 (mir-21) play a crucial role in the progression and aggressiveness of breast cancer, but its prognostic significance for patients with breast cancer remains inconclusive the aim of this meta-analysis is to summarize the role of circulating mir-21 as a molecular marker in patients with breast cancer.